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KMID : 1191520160210020063
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Journal of Korean Traditional Oncology
2016 Volume.21 No. 2 p.63 ~ p.74
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A Case Report of Recurred Hepatocellular Carcinoma Patient Treated with Radio-Frequency Hyperthermia in Conjunction with Sorafenib
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Kim Jee-Hye
Lee Jong-Hoon
Joo Jong-Cheon
Lee Jeong-Bok
Cho Chong-Kwan
Yoo Hwa-Seung
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Abstract
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Objective : The purpose of this study is to report the effects of radio-frequency hyperthermia cancer treatment in conjunction with Sorafenib on hepatocellular carcinoma patient.
Method : The patient was diagnosed with hepatocellular carcinoma at S6/7 and treated with right posterior sectionectomy. After 4 months, tumor recurrence was found at S4, 5 and 8. After transarterial chemoembolization, the patient was prescribed Sorafenib (proprietary name Nexavar(R)) as well as proceeding with radio-frequency hyperthermia. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (AFP, PIVKA-II), natural killer (NK) cell activity, and numeric rating scales (NRS).
Results : After the treatment, tumor size was decreased accompanying by reducing the level of tumor markers (AFP, PIVKA-II). Major clinical symptoms were improved with increasing NK cell activity. There were no adverse events based on National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0.
Conclusion : This case suggests that radio-frequency hyperthermia has synergistic effect for the treatment of hepatocellular carcinoma patient in conjunction with Sorafenib.
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KEYWORD
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Hepatocellular carcinoma, Radio-frequency hyperthermia, Sorafenib, α-fetoprotein, PIVKA-ll, Natural killer cell activity
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